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Specifically, the system targets the NRF2 pathway for its antioxidant properties and HES1 for its anti-aging effects

Fundam Appl Toxicol 4, 394405

Additionally, it has been reported that OS affects epigenetic regulatory mechanisms involved in the regulation of pancreatic cell survival and insulin secretion, like DNA methylation, chromatin architectural modification, and non-coding RNA (Kowluru and Mishra, 2017)

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