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Summary: Retatrutide can cause a dose-dependent increase in resting heart rate, with Phase 2 trials reporting mean rises of approximately 5 to 7 beats per minute at higher doses, likely driven by its GLP-1 and glucagon receptor agonism

"What we have heard is that nearly a dozen companies are already ready with generic versions of Rybelsus, the oral drug," says Sheetal Sapale, vice-president at Pharmarack

This phenomenon, called tachyphylaxis or tolerance, doesn't mean the medication has failedit means your body has adapted, and your treatment strategy may need adjustment

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