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Activated PKA can directly phosphorylate the sulphonylurea receptor (SUR1 as well as a regulatory subunit of K + ATP channels, thereby reducing SUR1 affinity to ADP, and increasing activity of K ir6 -cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight

3 Ask your prescriber about the cardiovascular indication or Bridge eligibility If you have established cardiovascular disease and are overweight or obese, ask your provider whether the CV indication applies