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235 In recent years, both liraglutide and semaglutide have been approved in the USA to treat obesity given their ability to induce weight loss to a greater extent than other drug options and exhibit superior safety, and in both diabetic and non-diabetic individuals liraglutide and semaglutide have been recommended as the first-line drugs for obesity treatment

Safe, evidence-based approaches include following the NHS Eatwell Guide, undertaking at least 150 minutes of moderate-intensity exercise per week, and accessing NHS-commissioned Tier 2 weight management programmes

A total of 785 patients completed the 6-month double-blind phase

After incubation, 1 l trypsin (New England Biolabs) from a resuspension in 500 l reaction buffer was added to each well, and emission at the same wavelengths at 37 C was measured again until values plateaued