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MDR1 (also known as ABCB1 or ATP Binding Cassette Subfamily B Member 1) encodes P-glycoprotein (P-gp), a Ca 2+ -dependent efflux pump that has been associated with the development of resistance against anthracyclines, vinca alkaloids, actinomycin D, and paclitaxel resistance ( MDR cDNAs, a gene transfer experiment examined the effects of enhanced P-gp expression under the control of various eukaryotic promoters, which introduced MDR in cultured cells previously sensitive to chemotherapeutic agents ( Understanding the molecular mechanisms that result in the development of drug resistance is an increasingly important issue, which has been approached through the comprehensive genomics analysis of MDR cancer cells, including the epigenetics associated with drug resistance and the identification of MDR genes

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Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis

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