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Overexpression of ferroptosis suppressor protein 1 (FSP1) or cytosolic GPX4 stimulates the genesis of ferroptosis-resistant CD8 + T cells without compromising their function, while the depletion of ferroptosis sensitivity-promoting enzyme acyl-CoA synthetase long-chain family member 4 (ACSL4) protected CD8 + T cells from ferroptosis but impaired antitumor CD8 + T cell response (Drijvers et al., 2021)

By targeting key enzymes involved in OXPHOS, FAO, and redox homeostasis, miRNAs can alter mitochondrial function and reprogram cellular metabolism [10,11,12]

Possible Mild Side Effects Risk: Injection-site discomfort, headaches, or other mild reactions could occur, especially when first starting

Loading For deficiency without neurological features, the standard loading regimen is hydroxocobalamin 1mg intramuscularly three times a week for two weeks, six injections in total