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Nat Med (2021) 27(4):60115
CPT1A, an enzyme located on the outer mitochondrial membrane, plays a pivotal role in controlling the transport of long-chain fatty acids into mitochondria and is considered a rate-limiting enzyme for FAO (Lane et al
References and further reading For readers who want primary sources, look for recent meta-analyses of randomized trials of oral l-carnitine and literature reviews of ALCAR for cognition and propionyl forms for circulation and performance
Future research should prioritize high-quality and mechanistically informed clinical trials, and should explore novel delivery systems to maximize NACs therapeutic potential in the CNS
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