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The landmark PREDIMED trial -- a randomized controlled trial involving 7,447 participants -- demonstrated that a Mediterranean diet supplemented with EVOO (approximately 50 g/day) did not result in weight gain over nearly five years of follow-up, despite being an unrestricted-calorie, high-fat diet (Estruch et al., 2018)

Secondary NAD+deficiency in the inherited defect of glutamine synthetase

Understanding what these numbers mean and which concentrations actually deliver results prevents wasting money on ineffective formulations