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Risks : Because nasal delivery bypasses first-pass metabolism but still enters systemic circulation, users may still experience systemic side effects like nausea, flushing, and transient increases in blood pressure

[1] [2] Semaglutide mimics the action of the naturally occurring hormone GLP-1, which is released from the intestine in response to food intake

Cardiomyopathy, cardiac arrhythmia, (likely due to the accumulation of long-chain fatty acids and acylcarnitines that cannot be oxidized), cardiac insufficiency and respiratory distress arise from CAC deficiency [120]

Combined oral contraceptives (COCs) are first-line treatments for PCOS, effectively lowering androgen levels and restoring menstrual regularity