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Available at: [34] Bond, P., Smit, D.L., de Ronde, W

Its fundamental pharmacological mode of action hinges on selective NNMT suppression: blocking excessive nicotinamide methylation reactions to elevate endogenous intracellular nicotinamide reserves, further accelerating downstream NAD+ biosynthesis

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Furthermore, how these changes contribute to neurodevelopmental changes leading to psychiatric disorders remains to be elucidated, but there are substantial overlaps between the assembly of the gut microbiome postnatally and important neurodevelopmental time windows [222, 223]