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Moreover, the interaction between hyperglycemia-driven immune impairment and hypoxic niches highlights a vicious cycle for pathogen recalcitrance, yet prevalent therapies fail to account for this multifactorial etiology, requiring integrated strategies that target both microbial and host determinants for durable outcomes
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Curr Med Chem 27:11741205 Constance JE, Lim CS (2012) Targeting malignant mitochondria with therapeutic peptides
Experimentally, other stress paradigms such as hemorrhage, oxidative stress, intraperitoneal hypertonic saline, restraint/immobilization, foot shock, forced swimming, or shaking are used to study the stress responses in animals
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