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Radiat Res 114:114124 Spitz DR, Adams DT, Sherman CM, Roberts RJ (1992) Mechanisms of cellular resistance to hydrogen peroxide, hyperoxia, and 4-hydroxy-2-nonenal toxicity: the significance of increased catalase activity in H 2 O 2 -resistant fibroblasts

Peroxynitrite can initiate DNA damage, leading to the stimulation of a nuclear enzyme, poly (ADP-ribose) synthase (PARS), which causes a decrease in cellular energy levels and leads to cell death

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Tryptophan-Derived Neurotransmitters Tryptophan serves as the precursor for the synthesis of serotonin (5-hydroxytryptamine, 5-HT, see also Biochemistry of Nerve Transmission) and melatonin ( N -acetyl-5-methoxytryptamine)