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However, this approach faces several challenges, including the potential for the blood-brain barrier (BBB) to mask or dilute CNS-specific signals and the difficulty in distinguishing brain-derived markers from those originating systemically (87,88)

[DOI] [PubMed] [Google Scholar] 189.Nakayama K, Tagawa R, Saito Y, Sanbongi C

The improvement of patients LBP symptoms and function occurred as early as 8 weeks after treatment, and the effect could be maintained for at least one year