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Tirzepatide has not yet completed a comparable cardiovascular outcomes trial, though studies are underway and early signals are promising

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The gene expression of microsomal triglyceride transfer protein, and carnitine palmitoiltransferase (CPT I) catalytic activity are reduced in the liver of cachectic rats, which also show increased liver (150%) and plasma (3.3-fold) triacylglycerol content

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