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The SURPASS-2 trial showing tirzepatide achieving significantly greater HbA1c reduction and weight loss than semaglutide in T2DM patients, and the SURMOUNT trials showing up to 22% average body weight reduction in obese patients, have established tirzepatide as the clinical performance leader in the class

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Often, these seemingly disconnected symptoms share a common underlying driver: a hyperactive immune system and the dysregulation of mast cells, leading to a condition known as mast cell activation syndrome (MCAS) or severe histamine intolerance