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The modulation of ion channels, specifically PIEZO1 and the Gardos channel, offers a promising strategy to restore ionic equilibrium, mitigate cellular dehydration, and enhance deformability in conditions such as sickle cell disease and hereditary xerocytosis (17, 35)

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25 and Fig

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Seizures, if recurrent, should be treated with intravenous benzodiazepines, and status epilepticus should be managed according to established protocols (Meierkord et al., 2010)

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