Based on the knowledge that Ca 2+ /calmodulin-dependent protein kinase 2 induces phosphorylation of AMPK and that AMPK, SIRT1, and PGC1 are part of a highly coordinated regulatory network [181,318], the authors proposed that the effects of OLE in chicken muscle cells may be due to induction of Ca 2+ influx, possibly through the activation of TRPV1 localized at ER, and increased activity of AMPK, followed by SIRT1 activation and then activation of PGC1 and induction of downstream mitochondrial targets [317]
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Glutathione has anti-inflammatory properties
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