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Since the lips and the perioral area are always visible and play an important role in facial expressions and communication, pigmentation in these areas can sometimes cause emotional discomfort or distress for affected individuals

Health status considerations: Generally healthy adults with physician clearance, individuals without contraindications (pregnancy, active malignancy, severe organ disease), those willing to commit to proper administration protocols and monitoring, and patients who understand the research-purposes-only status and informed consent requirements

Constipation or bloating can also happen as digestion becomes slower

doi: 10.1159/000053283