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Anyone considering this supplement should factor both of those realities into their decision: promising preclinical signal, very limited human clinical confirmation, no significant adverse effects observed in the small human studies that do exist

McConnell SA, Brandner AJ, Blank BA, Kearns DN, Koob GF, Vendruscolo LF, et al

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The organic phase and the aqueous phase are pumped so that the two phases flow simultaneously through a static mixer, thereby forming an emulsion which comprises microspheres containing the active pharmaceutical agent encapsulated in the polymeric matrix material