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One study found that -cell GLP-1r were necessary for surgery-induced improvements in glucose tolerance and glucose-stimulated insulin secretion, but not weight loss (69)

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Absolute contraindications to GLP-1 receptor agonists include: Personal history of medullary thyroid carcinoma Family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Pregnancy (for weight management indications) Severe gastrointestinal disease, including gastroparesis Patients should be specifically questioned about these conditions during pre-treatment evaluation