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Metformin has separately shown wound healing benefits: a 2021 randomized trial (N=108) of topical metformin on diabetic foot ulcers found a 52% complete healing rate at 12 weeks versus 31% with standard care alone (P=0.02) [11]

Additionally, studies report that insufficient sleep duration in pregnant women is associated with an increased risk of low birth weight in their offspring [54]

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