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Practical timeline expectations For researchers who decide to proceed with a combined protocol despite the unknown risks, realistic timeline expectations help set appropriate milestones for evaluation

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However, long-term NNMT inhibition in humans hasn't been characterized beyond small pilot cohorts, so concerns about sustained NAD+ elevation (which could theoretically promote certain cancers via PARP or SIRT activation) remain speculative but unresolved

Weight can come from: Body fat Lean muscle tissue Water Preserving muscle mass is important because muscle supports: Metabolism Strength Physical function Long-term weight maintenance This is why resistance training is frequently encouraged as part of a comprehensive plan