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Its proposed mechanisms involve multiple cytoprotective pathways including upregulation of VEGF and growth factors promoting angiogenesis, modulation of the nitric oxide system, activation of the FAK-paxillin pathway for cell migration and tissue repair, interaction with the gut-brain axis affecting dopaminergic and serotonergic systems, and gastroprotective effects against NSAID and alcohol-induced mucosal damage

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IRB and IACUC Protocols: Researchers conducting animal model studies with peptides are required to obtain appropriate Institutional Review Board (IRB) or Institutional Animal Care and Use Committee (IACUC) approvals