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Freezing causes the peptide proteins to unfold and clump together, which destroys the medications structure and makes it ineffective

These include temporary redness, mild swelling, occasional bruising, and slight burning sensation during administration

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NICE guidance on obesity management (CG189) emphasises evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, andwhere appropriatepharmacotherapy with licensed medications such as orlistat or semaglutide (NICE TA875)