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N Engl J Med 389(6):514526 Rosenstock J, Frias J, Jastreboff AM, Du Y, Lou J, Gurbuz S et al (2023) Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA
A possible explanation for this discrepancy might be the ferroptosis inducer, which was the pharmacological inhibition of GPX4 and xCT by RSL3 and erastin, respectively, in the study by Tsoi and colleagues [122] in contrast to glutathione depletion by BSO, cystine withdrawal or Gclc knockout in my study