In this context, it has been demonstrated that the restoration of -cell mass can occur not only through proliferation of existing -cells but also via transdifferentiation of other pancreatic cell types, such as -, -, PP-, and ductal epithelial cells (Figure 1B)
[16] They include: [16] Neonatal hyperbilirubinemia, where the newborn's liver is not able to properly process the bilirubin causing jaundice Hepatocellular disease Viral infections (hepatitis A, B, and C) Chronic alcohol use Autoimmune disorders Genetic syndromes: Gilbert's syndrome a genetic disorder of bilirubin metabolism that can result in mild jaundice, found in about 5% of the population Rotor syndrome: non-itching jaundice, with rise of bilirubin in the patient's serum, mainly of the conjugated type DubinJohnson syndrome CriglerNajjar syndrome Pharmaceutical drugs (especially antipsychotic, some sex hormones, and a wide range of other drugs) Sulfonamides are contraindicated in infants less than 2 months old (exception when used with pyrimethamine in treating toxoplasmosis) as they increase unconjugated bilirubin leading to kernicterus
In conclusion, our results support that systemically administered SEM may cause a systemic effect leading to a delayed increase in IOP, prevention of IOP-induced astrocyte remodeling and some retinal vasoprotection
doi: 10.1016/j.ijpharm.2021.121115 94
