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These limitations can be improved through glycosylation modification

Ethics statement All experimental procedures were approved by the Ethical Committee of the Faculty of Veterinary Medicine of the University of Ghent, Belgium (approval number EC2011-113) and carried out in accordance with the approved guidelines and regulations

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For the hepsin / mice, the timing of mortality was such that it occurred prior the onset of liver repair and regeneration processes, thereby confirming the role of hepsin in determining the mechanism of APAP toxicity tolerance during the early phase of drug exposure