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Manifestations include profound neutropenia, mucositis, diarrhea, and neurotoxicity

Notably, recent work from our own laboratory has demonstrated that alongside proteins that are either gained and/or modified during post-testicular sperm maturation, the shedding of proteins also constitutes a major part of the proteomic changes that contribute to producing a fertilization competent sperm cell (57, 109)

Hiratzka L, Bakris G, Beckman J, Bersin R, Carr V, Casey D, Eagle K, Hermann L, Isselbacher E, Kazerooni E, Kouchoukos N, Lytle B, Milewicz D, Reich D, Sen S, Shinn J, Svensson L, Williams D, Jacobs A, Smith S, Anderson J, Adams C, Buller C, Creager M, Ettinger S, Guyton R, Halperin J, Hunt S, Krumholz H , Kushner F, Lytle B, Nishimura R, Page R, Riegel B, Stevenson W, Tarkington L, Yancy C