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Both lowering the concentration of reductive molecules in the TME and increasing local O 2 levels enhance the potential for ROS generation, providing a foundation for improved SDT efficacy and ICD

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110 In the process of tumor evolution, DNA copy number loss, transcript repression, epigenetic silencing, and whole-genome doubling are different ways for potential malignant cells to acquire immune evasion and fueling adaptive abilities in response to various pressure