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In addition to drug-induced pigmentation and smoking-induced melanosis described earlier, a differential diagnosis of diffuse or multi-focal mucosal hyperpigmentation may include endocrinopathies such as hypoadrenocorticism and Cushing disease, genetic dysfunction (Peutz-Jeghers syndrome) and idiopathic etiology (Laugier-Hunziker pigmentation)

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Most people who were on moderate tirzepatide doses (5 to 10 mg) reach a semaglutide dose that provides equivalent appetite control somewhere between weeks 9 and 16