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The future of combination peptide therapies for metabolic health Tirzepatide represents current state-of-the-art dual-agonist therapy, but the field continues evolving rapidly

In the area of antihepatic fibrosis, ISL could inhibit Annexin A2 expression and block the sphingosine kinases/sphingosine-1-phosphate/IL-17 signaling pathway (Liu et al., 2023), yet, QE decreased hepatic mRNA levels of SphK1 and NLRP3 (Salama et al., 2024)

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