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Oral and injectable forms may cause mild digestive discomfort or injection site reactions, and unknown systemic effects or interactions with medications cannot be ruled out

Translating animal research for human application is seldom uncomplicatedvariations in metabolism, immune response, and peptide absorption can markedly alter the compounds behavior in humans

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SUMMIT: Tirzepatide and heart failure with preserved ejection fraction SUMMIT (Packer et al., NEJM 2024, NEJMoa2410027, PMID 39555826) randomized 731 patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 to tirzepatide up to 15 mg/week or placebo, with a median follow-up of 104 weeks