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Titration schedules in phase 3 trials of long acting insulin analogues incorporated individualization to allow the clinician to increase the dose to achieve optimal benefit without causing hypoglycaemia ( The oral obesity medications The oral GLP-1 based agents approved for obesity treatment deliver substantial weight loss

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Additionally, mortality rates for strokes that occur during the morning were significantly higher, even when adjusted for sex, severity, and age (Turin et al., 2012)