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Neuroinflammation 10, 815

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Thus, the wildtype strain for NNT, the 6N substrain, generates more oxidant stress during APAP hepatotoxicity and suffers more severe liver injury compared to the NNT-deficient 6J substrain [132]

Chronic Oxidative Stress (Depletes Glutathione Faster Than Its Made) Anything that increases free radical production depletes glutathione: Chronic inflammation (autoimmune diseases, obesity, metabolic syndrome) Environmental toxins (air pollution, pesticides, heavy metals) Alcohol consumption (glutathione is rapidly depleted in liver detoxification) Poor diet (high in processed foods, seed oils, sugar) Intense exercise (without adequate recovery) When oxidative stress exceeds your bodys capacity to recycle GSSG back to GSH, levels drop [4]