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Potential breaking of weight-loss plateaus, especially when standard diet/exercise alone have slowed

The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism

Cycle Length and Long-Term Use: Initial assessment cycles typically run 12-16 weeks, which aligns with the duration of clinical trials and allows adequate time to evaluate metabolic response and body composition changes