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The side effects, which are likely to subside over time, may include: Nausea Diarrhea Constipation Vomiting Heartburn Headaches GERD (Gastroesophageal reflux disease) Starting at low doses may help circumvent these, says Kushner, who also notes that these side effects can usually be alleviated if people eat low-fat foods, smaller portion sizes, and a balanced meal plan

For broader treatment placement in type 2 diabetes, see Injectable Type 2 Diabetes for context on when GLP-1 RAs complement other classes

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Despite these benefits, their use in women planning pregnancy is complicated by uncertainty regarding reproductive safety, the optimal timing of discontinuation, and the most effective alternatives to maintain metabolic health after withdrawal [7,8]