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Given that the acetylation level of Small Mother Against Decapentaplegic (Smads) transcription factors is crucial for the events\triggered by TGF- receptor 2 (TGFR2) and TGFR1 activation, sirtuins, as constitutive deacetylases, may play a key role in regulating the activation of Smad2, Smad3, Smad4 and Smad7 and translocation of the Smad2/3 complex to the nucleus 41

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7.4 Catestatin and autonomicmetabolic regulation Catestatin, a peptide derived from the prohormone chromogranin A, inhibits catecholamine release and modulates sympathetic tone