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As a transcription factor, Nrf2 can activate Nrf2-ARE-regulated genes, exerting an inhibitory effect on inflammatory factors and providing a defence against oxidative stress, which is essential for enhancing the antioxidant capacity of cells [111]

Food and Drug Administration) for managing type 2 diabetes mellitus, reducing the risk of cardiovascular diseases such as heart attack, stroke, hypertension, myocardial infarction, and death and lowering the risk of kidney failure or worsening kidney disease in patients with chronic kidney disease

It is not available in Scotland, Wales, Northern Ireland, or outside the UK

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