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Lipin-1 contributes to IL-4 mediated macrophage polarization

It achieves this by controlling the expression of pluripotency genes through the regulation of GSH homeostasis and the suppression of the mesoderm-inducing protein Brachyury ( The significance of CHAC2-NRF2 signaling pathway extends beyond development

Metabolome reflects the ongoing (patho)physiological state of the body or of a cell/tissue, and provides valuable insights into the biochemical processes underlying a disease that potentially could be used as targets for drug development 22,23