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Switching Requires Medical Guidance: Transitioning involves stopping the first medication, potentially having a washout period, and starting the new medication (Zepbound) at the lowest dose, followed by gradual titration under a provider's supervision

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In pregnant rabbits given once weekly subcutaneous doses of 0.01, 0.03, or 0.1 mg/kg tirzepatide (0.01-, 0.06-, and 0.2-fold the MRHD) during organogenesis, pharmacologically-mediated effects on the gastrointestinal system resulting in maternal mortality or abortion in a few rabbits occurred at all dose levels