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Description

Update on immunotherapy in melanoma

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In preclinical experiments, icotrokinra bound to the IL-23R with high affinity ( K D = 7.1 pM) and demonstrated exquisite potency and selective inhibition of proximal IL-23 signaling (IC 50 = 5.6 pM) in human peripheral blood mononuclear cells without affecting IL-12 signaling [80]

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