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Validating robust, non-invasive biomarkers (e.g., circulating lipid peroxide metabolites, urine exosomal ferroptosis regulators, or TME-derived immune cell ferroptosis signatures) is urgently needed to guide clinical trial design and patient stratification

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Drosophila melanogaster glutamate-cysteine ligase activity is regulated by a modifier subunit with a mechanism of action similar to that of the mammalian form