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As Aft puts it, the traditional core assets remain foundational but are no longer sufficient on their own

doi: 10.3389/fonc.2026.1680441 Received 06 August 2025 Revised 20 January 2026 Accepted 20 January 2026 Published 03 February 2026 Volume 16 - 2026 Edited by Arumugam Jayakumar, University of Texas MD Anderson Cancer Center, United States Reviewed by Enrico Martin, University Medical Center Utrecht, Netherlands Fei Song, Affiliated Hospital of Nantong University, China Updates Copyright 2026 Zhu, Shen, Yang, Han, Li, Xie, Tan, Lu, Ji and Zhang

523 have reported that SETD8 interacts with STAT3 and induces monomethylation of H4K20 on DUSP10 promoter, thereby promoting epigenetic silencing of DUSP10 (Dual Specificity Phosphatase 10)

Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S