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Your oxidative stress levels, nutrient status, and detox capacity all play a role

Controlled human trials exist, but they're limited in size, focused mostly on topical cosmetic use, and usually last only a few weeks or months. That means a lot of the exciting claims, especially around gene expression, systemic repair, and anti-aging effects, haven't been confirmed in large-scale human studies

Perera F, Nolte ELR, Wang Y et al (2016) Bisphenol A exposure and symptoms of anxiety and depression among inner city children at 1012 years of age

For references and more information , see the section on homocysteine in the Vitamin B 12 article