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It's not yet clear what long-term pharmaceutical GLP-1 agonist drug use looks like from a safety perspective

Poliosis itself is simply a harmless lack of pigment in hair follicles, which causes them to become white or gray

Cleveland Clinic: Hypothyroidism National Institute of Diabetes and Digestive and Kidney Diseases: Hypothyroidism (Underactive Thyroid) Endocrine Society: Hypothyroidism and the Heart American Thyroid Association: Can Vitamin D Supplementation Prevent Autoimmune Thyroid Disease Leading to Hypothyroidism