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In chronic PD mice, the triple receptor agonist HM15211 protected against dopaminergic neuronal death, decreased -synuclein accumulation, and prevented nigrostriatal neurodegeneration by mitigating the inflammatory response and lipid peroxidation [124, 125]

Quality control and processing of scRNA-seq 96 intestinal scRNA-seq data were processed by Seurat package (v5.1.0)

These insights are particularly relevant in studies focused on melanocortin system regulation and its broader biological impact

However, these results differ from previous results, which revealed that oral L-carnitine supplementation had no effect on weight loss during calorie restriction in impaired glucose metabolic patients [31] and during aerobic training in obese women [32]