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These changes are enhanced by modifications in key regions such as the insular cortex (main area for taste processing) and caudate nucleus, where GLP-1-RAs are capable of normalizing altered brain activation patterns in patients with obesity and diabetes mellitus when exposed to hedonic gustatory stimuli (173, 174)

Semaglutide is available in both injectable and oral forms, but there are some key differences in pricing and accessibility that patients should consider

Some clinicians and researchers explore split semaglutide dosing twice weekly or split tirzepatide dosing as a way to maintain more consistent blood levels and potentially improve results while reducing peak-dose side effects