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The intracellular C-terminal domain interacts with intracellular signaling proteins, initiating downstream signaling pathways [4]

In addition to components of the PDHc itself, mutations in the gene (PDP1) encoding one of the catalytic subunits of the major PDH phosphatase and mutations in the gene (PDHX) that encodes a E3 subunit binding protein, have been shown to be associated with PDH deficiency syndromes

From research to practice At Caron, patients now receive GLP-1 medications, administered either once daily or once weekly, alongside established therapies such as cognitive-behavioral therapy and traditional 12-step programs

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