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(29) Female mice were fed a high-fat diet to induce obesity and type 2 diabetes before being treated with semaglutide (10 nmol/kg) or insulin (0.5 U/kg) for up to 28 days

That distinction remains a major point of debate among clinicians, regulators, and pharmaceutical manufacturers

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Zepbound is a combined glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for chronic weight management in adults who are obese or overweight with at least one weight-related condition, such as high blood pressure, type 2 diabetes, high cholesterol, or cardiovascular disease and is to be used in addition to a reduced calorie diet and increased physical activity