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By attenuating enkephalin catabolism, Selank effectively prolongs the biological activity of endogenous opioid peptides: Increased leu-enkephalin half-life in blood plasma observed in clinical study participants Enkephalin-related effects on anxiety appear independent of direct opioid receptor activation Studies in morphine-dependent rats showed Selank (0 Anxiety and Stress Research Generalized Anxiety Disorder Models The most extensively studied application of Selank is its anxiolytic activity across multiple preclinical models and in a limited number of clinical investigations conducted in Russia